Tadaga 5 mg, a medication containing tadalafil, can interact with several drugs and cause serious health risks if not used cautiously. You should avoid nitrates (like nitroglycerin for chest pain), as combining them with Tadaga can lead to a dangerous drop in blood pressure. Also avoid alpha-blockers, often used for high blood pressure or prostate issues, unless supervised by a doctor. Certain antifungal medications (like ketoconazole), antibiotics (such as erythromycin), and HIV protease inhibitors can increase tadalafil levels in your blood, raising the risk of side effects. Always consult your healthcare provider before combining medications.